A BAYESIAN MIXED MODELING APPROACH FOR ESTIMATING HERITABILITY

A Bayesian mixed modeling approach for estimating heritability

Abstract Background A Bayesian mixed model approach using integrated nested Laplace approximations (INLA) allows us to construct flexible models that can account for pedigree structure.Using these models, we estimate genome-wide patterns of DNA methylation heritability (h 2 ), which are currently not well understood, as well as h 2 of blood lipid m

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Promoter methylation, transcription, and retrotransposition of LINE-1 in colorectal adenomas and adenocarcinomas

Abstract Background The methylation of the CpG islands of the LINE-1 promoter is a tight control mechanism on the function of mobile elements.However, simultaneous quantification of promoter methylation and transcription of LINE-1 has not been performed in progressive stages of colorectal cancer.In addition, the insertion of mobile elements in the

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